{"id":9804,"date":"2024-01-25T14:30:00","date_gmt":"2024-01-25T06:30:00","guid":{"rendered":"https:\/\/credevo.com\/articles\/?p=9804"},"modified":"2024-05-17T11:45:22","modified_gmt":"2024-05-17T03:45:22","slug":"exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility","status":"publish","type":"post","link":"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/","title":{"rendered":"Exploring Investigator-Initiated Clinical Trials (IITs) &#038; Assessing Feasibility"},"content":{"rendered":"\n<p>Executing an IIT is often more complex for various reasons, including the necessity for industry support. Therefore, conducting an early feasibility assessment\/evaluation before commencing an IIT can help address most challenges. Investigator-initiated trials (IITs) are typically conducted at academic hospitals and universities, distinguishing them from regular clinical trials in several aspects.<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo-1024x576.png\" alt=\"Investigator_initiated Clinical Trials &amp; Feasibility Assessment\" class=\"wp-image-9810\" srcset=\"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo-1024x576.png 1024w, https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo-300x169.png 300w, https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo-768x432.png 768w, https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo-1536x864.png 1536w, https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo-732x412.png 732w, https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo-1140x641.png 1140w, https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo.png 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">What are Investigator-Initiated Trials (IITs)?<\/h2>\n\n\n\n<p>Investigator-initiated studies are ideas developed by researchers and investigators in laboratories and clinics. The trial&#8217;s sponsor investigator is both sponsoring and conducting the study.&nbsp;They will be in charge of developing, coordinating, and implementing the IIT. This can be done alone or with a team assisting the sponsor investigator.<\/p>\n\n\n\n<p>There are multiple terms for the studies undertaken by investigators like<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>IIT &#8211; Investigator-initiated Initiated Trials<\/li><li>IIR &#8211; Investigator-Initiated Research <\/li><li>PIT &#8211; Physician Initiated Trials<\/li><li>IST &#8211; Investigator Sponsored Trial<\/li><li>IIS &#8211; Investigator-Initiated Studies<\/li><li>ISR &#8211; Investigator Sponsored Research<\/li><li>ISS &#8211; Investigator Sponsored Study<\/li><li>ERP &#8211; External Research Programs<\/li><li>Independent studies<\/li><\/ul>\n\n\n\n<p>The key advantages of IIT over company-sponsored studies are listed below:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A successful IIT offers various advantages over a traditional clinical trial, frequently filling gaps left by unsolved issues from a previous trial.&nbsp;<\/li><li>IITs allow investigating the usage of commercial medications for new indications, in subsections of approved populations, and innovative combinations with existing treatments.<\/li><li>IITs can help to develop new diagnostic tools and methods.<\/li><li>Provide clinical data to pharmaceutical companies to better understand their products in the real world.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Principal roles in an Investigator-Initiated Trial\u00a0<\/h2>\n\n\n\n<p>An investigator-initiated trial has three key roles: the sponsor investigator, the investigator, and the sponsor. <\/p>\n\n\n\n<p>The detailed responsibilities for each role are listed in the table below.<\/p>\n\n\n\n<figure class=\"wp-block-table is-style-regular\"><table class=\"has-blush-light-purple-gradient-background has-background\"><thead><tr><th><strong>IIT Sponsor Investigator<\/strong><\/th><th><strong>IIT Sponsor<\/strong><\/th><th><strong>IIT Investigator<\/strong><\/th><\/tr><\/thead><tbody><tr><td>Accountable for all sponsorship and regulatory requirements, including funding<\/td><td>Ensure human subjects&#8217; safety<\/td><td>Maintains patient records and controls the therapies\/drugs being investigated<\/td><\/tr><tr><td>Conceive and create the study framework<\/td><td>Selection of qualified investigators<\/td><td>Monitors compliance with the study&#8217;s protocols and investigative plan<\/td><\/tr><tr><td>Coordinate the study<\/td><td>Monitor the progress of the study<\/td><td>Submits various documents including progress reports, safety reports, and financial disclosures<\/td><\/tr><tr><td>Conduct the study<\/td><td>Documentation of the study<\/td><td>Responsible for obtaining informed consent from subjects&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">What are the differences between Sponsor-Initiated Trials and Investigator-Initiated Trials<\/h2>\n\n\n\n<p>The following are some key differences between sponsor-initiated clinical trials and investigator-initiated trials:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-pale-ocean-gradient-background has-background\"><thead><tr><th>Category<\/th><th><strong>Sponsor-Initiated Trials<\/strong><\/th><th><strong>Investigator-Initiated Trials<\/strong><\/th><\/tr><\/thead><tbody><tr><td><strong>Data<\/strong><\/td><td>The sponsor owns CRFs and reports that the sponsor provides; the Institution owns medical records and other data&nbsp;<\/td><td>The university owns the protocol, documents, research results, and data<\/td><\/tr><tr><td><strong>Funding<\/strong><\/td><td>Sponsor<\/td><td>Grants; Industry Funding; University; Department<\/td><\/tr><tr><td><strong>IND\/IDE Holder<\/strong><\/td><td>Sponsor<\/td><td>Investigator<\/td><\/tr><tr><td><strong>Intellectual Property<\/strong><\/td><td>The sponsor owns patentable inventions conceived and reduced to practice; the institution owns everything else.<\/td><td>The university owns all inventions and intellectual property<\/td><\/tr><tr><td><strong>Injuries and Indemnifications<\/strong><\/td><td>The sponsor pays unless non-compliance, negligence, or misconduct on the part of the PI or the institution causes the damage<\/td><td>No compensation for injuries is provided<\/td><\/tr><tr><td><strong>Protocol Author<\/strong><\/td><td>Sponsor<\/td><td>Investigator<\/td><\/tr><tr><td><strong>Study type<\/strong><\/td><td>Often investigates a new drug&#8217;s or medical product&#8217;s efficacy<\/td><td>Mostly comparative studies<\/td><\/tr><tr><td><strong>Timelines<\/strong><strong>&nbsp;&nbsp;<\/strong><\/td><td>Stringent timelines<\/td><td>Timelines may be extended due to delays in grant and regulatory applications<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Common challenges encountered in Investigator-Initiated Clinical Trials<\/h2>\n\n\n\n<p>The following are some challenges that arise when conducting an investigator-initiated trial:<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Inadequate internal support means that a multidisciplinary team of experts, including project managers, biostatisticians, data managers, pharmacists, and monitors, is needed. Thus, costs are increased significantly.<\/li><li>Lack of experience with the basic concepts behind clinical trials and their consequences, including safety monitoring, protocol and study design, study commencement and monitoring, ethical and legal issues, and data management.<\/li><li>Financial limitations because conducting a trial involves expenses for study equipment, lab testing, logistics, personnel, and other ancillary expenses.&nbsp;<\/li><\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">An early feasibility assessment &#8211; A better option to overcome Investigator-Initiated Trial (IIT) challenges<\/h2>\n\n\n\n<p>To generate a good IIT, investigators have to learn how to produce scientific value and establish robust guidelines to guide the study. Their network and economic limitations will force them to focus on upholding a strict efficiency standard.<\/p>\n\n\n\n<p>Considering the various challenges that result from the investigator&#8217;s inexperience in this area, it is best to approach IIT planning as a learning exercise.<\/p>\n\n\n\n<p>The investigator must possess advanced competence in multiple fields to initiate an IIT. An early feasibility assessment can assist in addressing the majority of the following obstacles like below:<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1. Study duration<\/h4>\n\n\n\n<p>Determining the overall time needed for clinical trial approval, certain regulatory requirements that can affect study site decisions, etc., is the aim of the study&#8217;s feasibility.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2. Epidemiology of the desired indication<\/h4>\n\n\n\n<p>Incidence and prevalence of indication, disease-specific patient population, classification of existing treatment regimens or guidelines, and accessibility to alternative drugs and therapies.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">3. Investigator feasibility<\/h4>\n\n\n\n<p>Evaluations of the investigator&#8217;s expertise about standard care (drug type, dosage, etc.), the real study population in contrast to the patient population treated or experienced by the potential investigator, and the investigator&#8217;s expertise with technology and tools are all part of the investigator-level feasibility assessment.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">4. Site feasibility<\/h4>\n\n\n\n<p>Demographics about the site help to determine the nature of clinical practice (hospital versus outpatient), prior clinical trial experience, and the presence of study coordinators, pharmacists, and nurses.<\/p>\n\n\n\n<p>This helps to determine the investigator&#8217;s or site&#8217;s &#8220;competency&#8221; in conducting the clinical trial, but not so much in terms of medical expertise as in protocol-related knowledge, personnel availability, etc.<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\"\/>\n\n\n\n<blockquote class=\"wp-block-quote has-text-align-center is-style-large is-layout-flow wp-block-quote-is-layout-flow\"><p><a href=\"https:\/\/credevo.com\/articles\/2018\/10\/31\/clinical-trial-feasibility-important-tool-before-you-conduct-clinical-trial\/\" target=\"_blank\" rel=\"noreferrer noopener\">Click here to learn more about the clinical trial feasibility: why and how to conduct them.<\/a><\/p><\/blockquote>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">5. Patient Recruitment And Retention<\/h4>\n\n\n\n<p>The most important element of the site feasibility is the part that centers on recruiting and retention. It is particularly useful in assessing the potential for recruitment in terms of predicted participants each month and across the trial.<\/p>\n\n\n\n<p>It aids in choosing whether we want to research more sites and evaluate site performance while a study is ongoing.<\/p>\n\n\n\n<p>The additional information covered ethical concerns, comparative studies, previous experience doing analogous investigations, and more.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">6. Infrastructure of the site<\/h4>\n\n\n\n<p>The most important element of the site feasibility is the part that centers on recruiting and retention. It is particularly useful in assessing the potential for recruitment in terms of predicted participants each month and across the trial.<\/p>\n\n\n\n<p>It aids in choosing whether we want to research more sites and evaluate site performance while a study is ongoing.<\/p>\n\n\n\n<p>The additional information covered ethical concerns, comparative studies, previous experience doing analogous investigations, and more.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">7. Quality:\u00a0<\/h4>\n\n\n\n<p>Another factor to examine is whether a site has undertaken sponsor or independent site audits previously. Second, the <a href=\"https:\/\/www.fda.gov\/\" target=\"_blank\" rel=\"noreferrer noopener\">FDA<\/a>, <a href=\"https:\/\/www.ema.europa.eu\/en\/homepage\" target=\"_blank\" rel=\"noreferrer noopener\">EMA<\/a>, and a few other regulatory authorities have conducted site inspections in recent years.<\/p>\n\n\n\n<p>It could be an excellent strategy to find out if the site has suffered any of these and, if so, what difficulties have been raised. During the launch phase, this helps teams allocate appropriate resources and provide adequate training.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Conclusion<\/h2>\n\n\n\n<p>Traditional clinical trials profit from the abundance of industrial capital and knowledge. Because investigator-initiated trials lack these qualities, investigators must plan and execute their investigations with stricter discipline and greater efficiency. <\/p>\n\n\n\n<p>An IIS runs the risk of collapsing in these constraints. A smaller team, a lower budget, or a lack of experience may cause a study&#8217;s failure. However, when implemented properly, an IIT can solve a great deal of the clinical problems that doctors encounter in the real world. As a result, they are a crucial ability for a committed investigator to build up.<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">Do you need any further information or have any questions about Investigator-Initiated Clinical Trials (IITs)?<\/h2>\n\n\n\n<p>Are you unsure about how to proceed with this IIT or are you considering conducting a feasibility assessment for a go\/no-go decision? Feel free to provide your questions, doubts, or queries by filling out the form below to connect with our expert team.<\/p>\n\n\n<div class=\"wpforms-container wpforms-container-full\" id=\"wpforms-9809\"><form id=\"wpforms-form-9809\" class=\"wpforms-validate wpforms-form\" data-formid=\"9809\" method=\"post\" enctype=\"multipart\/form-data\" action=\"\/articles\/wp-json\/wp\/v2\/posts\/9804\" data-token=\"42595e29e4c70415f5e2361028bd6013\" data-token-time=\"1776790990\"><noscript class=\"wpforms-error-noscript\">Please enable JavaScript in your browser to complete this form.<\/noscript><div class=\"wpforms-field-container\"><div id=\"wpforms-9809-field_6-container\" class=\"wpforms-field wpforms-field-textarea\" data-field-id=\"6\"><label class=\"wpforms-field-label\" for=\"wpforms-9809-field_6\">What kind of support are you looking for? <span class=\"wpforms-required-label\">*<\/span><\/label><textarea id=\"wpforms-9809-field_6\" class=\"wpforms-field-medium wpforms-field-required\" name=\"wpforms[fields][6]\" required><\/textarea><\/div><div id=\"wpforms-9809-field_7-container\" class=\"wpforms-field wpforms-field-text\" data-field-id=\"7\"><label class=\"wpforms-field-label\" for=\"wpforms-9809-field_7\">What is your company\/organization name? <span class=\"wpforms-required-label\">*<\/span><\/label><input type=\"text\" id=\"wpforms-9809-field_7\" class=\"wpforms-field-medium wpforms-field-required\" name=\"wpforms[fields][7]\" required><\/div><div id=\"wpforms-9809-field_1-container\" class=\"wpforms-field wpforms-field-email\" data-field-id=\"1\"><label class=\"wpforms-field-label\" for=\"wpforms-9809-field_1\">What is your work email? <span class=\"wpforms-required-label\">*<\/span><\/label><input type=\"email\" id=\"wpforms-9809-field_1\" class=\"wpforms-field-medium wpforms-field-required\" name=\"wpforms[fields][1]\" spellcheck=\"false\" required><div class=\"wpforms-field-description\">Provide your work email, where we can contact you<\/div><\/div><\/div><!-- .wpforms-field-container --><div class=\"wpforms-field wpforms-field-hp\"><label for=\"wpforms-9809-field-hp\" class=\"wpforms-field-label\">Email<\/label><input type=\"text\" name=\"wpforms[hp]\" id=\"wpforms-9809-field-hp\" class=\"wpforms-field-medium\"><\/div><div class=\"wpforms-recaptcha-container wpforms-is-recaptcha wpforms-is-recaptcha-type-v2\" ><div class=\"g-recaptcha\" data-sitekey=\"6LeaQRYTAAAAAPo7U8jnZJBUndxcS3f0E3Vijb2k\"><\/div><input type=\"text\" name=\"g-recaptcha-hidden\" class=\"wpforms-recaptcha-hidden\" style=\"position:absolute!important;clip:rect(0,0,0,0)!important;height:1px!important;width:1px!important;border:0!important;overflow:hidden!important;padding:0!important;margin:0!important;\" data-rule-recaptcha=\"1\"><\/div><div class=\"wpforms-submit-container\" ><input type=\"hidden\" name=\"wpforms[id]\" value=\"9809\"><input type=\"hidden\" name=\"page_title\" value=\"\"><input type=\"hidden\" name=\"page_url\" value=\"https:\/\/credevo.com\/articles\/wp-json\/wp\/v2\/posts\/9804\"><input type=\"hidden\" name=\"url_referer\" value=\"\"><button type=\"submit\" name=\"wpforms[submit]\" id=\"wpforms-submit-9809\" class=\"wpforms-submit\" data-alt-text=\"Sending...\" data-submit-text=\"Submit\" aria-live=\"assertive\" value=\"wpforms-submit\">Submit<\/button><\/div><\/form><\/div>  <!-- .wpforms-container -->\n\n\n\n<hr class=\"wp-block-separator is-style-wide\"\/>\n","protected":false},"excerpt":{"rendered":"<p>Executing an IIT is often more complex for various reasons, including the necessity for industry support. Therefore, conducting an early feasibility assessment\/evaluation before commencing an IIT can help address most challenges. Investigator-initiated trials (IITs) are typically conducted at academic hospitals and universities, distinguishing them from regular clinical trials in several aspects. What are Investigator-Initiated Trials [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":9810,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"cybocfi_hide_featured_image":"","footnotes":""},"categories":[12],"tags":[411,658,660],"class_list":["post-9804","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-trial","tag-feasibility","tag-iit","tag-investigator-initiatedclinicaltrial"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Investigator-Initiated Clinical Trials (IITs) &amp; Feasibility | Credevo Articles<\/title>\n<meta name=\"description\" content=\"Executing an IIT is often complex for various reasons and, conducting an early feasibility assessment helps address most challenges\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Investigator-Initiated Clinical Trials (IITs) &amp; Feasibility | Credevo Articles\" \/>\n<meta property=\"og:description\" content=\"Executing an IIT is often complex for various reasons and, conducting an early feasibility assessment helps address most challenges\" \/>\n<meta property=\"og:url\" content=\"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/\" \/>\n<meta property=\"og:site_name\" content=\"Credevo Articles\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/credevo\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-25T06:30:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-05-17T03:45:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Trial Expert\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@gocredevo\" \/>\n<meta name=\"twitter:site\" content=\"@gocredevo\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Trial Expert\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/\"},\"author\":{\"name\":\"Trial Expert\",\"@id\":\"https:\/\/credevo.com\/articles\/#\/schema\/person\/27532d20071183286988a29ea878a2ec\"},\"headline\":\"Exploring Investigator-Initiated Clinical Trials (IITs) &#038; Assessing Feasibility\",\"datePublished\":\"2024-01-25T06:30:00+00:00\",\"dateModified\":\"2024-05-17T03:45:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/\"},\"wordCount\":1295,\"publisher\":{\"@id\":\"https:\/\/credevo.com\/articles\/#organization\"},\"image\":{\"@id\":\"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo.png\",\"keywords\":[\"feasibility\",\"IIT\",\"Investigator-Initiatedclinicaltrial\"],\"articleSection\":[\"clinical trial\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/\",\"url\":\"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/\",\"name\":\"Investigator-Initiated Clinical Trials (IITs) & Feasibility | Credevo Articles\",\"isPartOf\":{\"@id\":\"https:\/\/credevo.com\/articles\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo.png\",\"datePublished\":\"2024-01-25T06:30:00+00:00\",\"dateModified\":\"2024-05-17T03:45:22+00:00\",\"description\":\"Executing an IIT is often complex for various reasons and, conducting an early feasibility assessment helps address most challenges\",\"breadcrumb\":{\"@id\":\"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/#primaryimage\",\"url\":\"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo.png\",\"contentUrl\":\"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo.png\",\"width\":1920,\"height\":1080,\"caption\":\"Investigator_initiated Clinical Trials & Feasibility Assessment\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/credevo.com\/articles\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Exploring Investigator-Initiated Clinical Trials (IITs) &#038; Assessing Feasibility\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/credevo.com\/articles\/#website\",\"url\":\"https:\/\/credevo.com\/articles\/\",\"name\":\"Credevo\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/credevo.com\/articles\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/credevo.com\/articles\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/credevo.com\/articles\/#organization\",\"name\":\"Credevo Pte. Ltd.\",\"url\":\"https:\/\/credevo.com\/articles\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/credevo.com\/articles\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2021\/04\/CREDEVO-HORIZONTAL.jpg\",\"contentUrl\":\"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2021\/04\/CREDEVO-HORIZONTAL.jpg\",\"width\":320,\"height\":119,\"caption\":\"Credevo Pte. Ltd.\"},\"image\":{\"@id\":\"https:\/\/credevo.com\/articles\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/credevo\",\"https:\/\/x.com\/gocredevo\",\"https:\/\/www.instagram.com\/credevo_official\/\",\"https:\/\/www.linkedin.com\/company\/credevo\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/credevo.com\/articles\/#\/schema\/person\/27532d20071183286988a29ea878a2ec\",\"name\":\"Trial Expert\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/credevo.com\/articles\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/07b120d666645220d4fd5b49e154d849?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/07b120d666645220d4fd5b49e154d849?s=96&d=mm&r=g\",\"caption\":\"Trial Expert\"},\"url\":\"https:\/\/credevo.com\/articles\/author\/trialexpert\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Investigator-Initiated Clinical Trials (IITs) & Feasibility | Credevo Articles","description":"Executing an IIT is often complex for various reasons and, conducting an early feasibility assessment helps address most challenges","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/","og_locale":"en_US","og_type":"article","og_title":"Investigator-Initiated Clinical Trials (IITs) & Feasibility | Credevo Articles","og_description":"Executing an IIT is often complex for various reasons and, conducting an early feasibility assessment helps address most challenges","og_url":"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/","og_site_name":"Credevo Articles","article_publisher":"https:\/\/www.facebook.com\/credevo","article_published_time":"2024-01-25T06:30:00+00:00","article_modified_time":"2024-05-17T03:45:22+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo.png","type":"image\/png"}],"author":"Trial Expert","twitter_card":"summary_large_image","twitter_creator":"@gocredevo","twitter_site":"@gocredevo","twitter_misc":{"Written by":"Trial Expert","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/#article","isPartOf":{"@id":"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/"},"author":{"name":"Trial Expert","@id":"https:\/\/credevo.com\/articles\/#\/schema\/person\/27532d20071183286988a29ea878a2ec"},"headline":"Exploring Investigator-Initiated Clinical Trials (IITs) &#038; Assessing Feasibility","datePublished":"2024-01-25T06:30:00+00:00","dateModified":"2024-05-17T03:45:22+00:00","mainEntityOfPage":{"@id":"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/"},"wordCount":1295,"publisher":{"@id":"https:\/\/credevo.com\/articles\/#organization"},"image":{"@id":"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/#primaryimage"},"thumbnailUrl":"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo.png","keywords":["feasibility","IIT","Investigator-Initiatedclinicaltrial"],"articleSection":["clinical trial"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/","url":"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/","name":"Investigator-Initiated Clinical Trials (IITs) & Feasibility | Credevo Articles","isPartOf":{"@id":"https:\/\/credevo.com\/articles\/#website"},"primaryImageOfPage":{"@id":"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/#primaryimage"},"image":{"@id":"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/#primaryimage"},"thumbnailUrl":"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo.png","datePublished":"2024-01-25T06:30:00+00:00","dateModified":"2024-05-17T03:45:22+00:00","description":"Executing an IIT is often complex for various reasons and, conducting an early feasibility assessment helps address most challenges","breadcrumb":{"@id":"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/#primaryimage","url":"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo.png","contentUrl":"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2024\/05\/Investigator_initiated_clinical_trials_feasibility_assessment_Credevo.png","width":1920,"height":1080,"caption":"Investigator_initiated Clinical Trials & Feasibility Assessment"},{"@type":"BreadcrumbList","@id":"https:\/\/credevo.com\/articles\/2024\/01\/25\/exploring-investigator-initiated-clinical-trials-iits-assessing-feasibility\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/credevo.com\/articles\/"},{"@type":"ListItem","position":2,"name":"Exploring Investigator-Initiated Clinical Trials (IITs) &#038; Assessing Feasibility"}]},{"@type":"WebSite","@id":"https:\/\/credevo.com\/articles\/#website","url":"https:\/\/credevo.com\/articles\/","name":"Credevo","description":"","publisher":{"@id":"https:\/\/credevo.com\/articles\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/credevo.com\/articles\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/credevo.com\/articles\/#organization","name":"Credevo Pte. Ltd.","url":"https:\/\/credevo.com\/articles\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/credevo.com\/articles\/#\/schema\/logo\/image\/","url":"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2021\/04\/CREDEVO-HORIZONTAL.jpg","contentUrl":"https:\/\/credevo.com\/articles\/wp-content\/uploads\/2021\/04\/CREDEVO-HORIZONTAL.jpg","width":320,"height":119,"caption":"Credevo Pte. Ltd."},"image":{"@id":"https:\/\/credevo.com\/articles\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/credevo","https:\/\/x.com\/gocredevo","https:\/\/www.instagram.com\/credevo_official\/","https:\/\/www.linkedin.com\/company\/credevo"]},{"@type":"Person","@id":"https:\/\/credevo.com\/articles\/#\/schema\/person\/27532d20071183286988a29ea878a2ec","name":"Trial Expert","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/credevo.com\/articles\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/07b120d666645220d4fd5b49e154d849?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/07b120d666645220d4fd5b49e154d849?s=96&d=mm&r=g","caption":"Trial Expert"},"url":"https:\/\/credevo.com\/articles\/author\/trialexpert\/"}]}},"_links":{"self":[{"href":"https:\/\/credevo.com\/articles\/wp-json\/wp\/v2\/posts\/9804"}],"collection":[{"href":"https:\/\/credevo.com\/articles\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/credevo.com\/articles\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/credevo.com\/articles\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/credevo.com\/articles\/wp-json\/wp\/v2\/comments?post=9804"}],"version-history":[{"count":6,"href":"https:\/\/credevo.com\/articles\/wp-json\/wp\/v2\/posts\/9804\/revisions"}],"predecessor-version":[{"id":9812,"href":"https:\/\/credevo.com\/articles\/wp-json\/wp\/v2\/posts\/9804\/revisions\/9812"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/credevo.com\/articles\/wp-json\/wp\/v2\/media\/9810"}],"wp:attachment":[{"href":"https:\/\/credevo.com\/articles\/wp-json\/wp\/v2\/media?parent=9804"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/credevo.com\/articles\/wp-json\/wp\/v2\/categories?post=9804"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/credevo.com\/articles\/wp-json\/wp\/v2\/tags?post=9804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}